Portrait of Maria Mascarenhas

Maria Mascarenhas

Medical Student · Researcher · São Paulo

I am a fourth-year medical student in São Paulo. I founded an ortho-regeneration research line to work on the joint disease I was told I might one day live with myself — and I divide my work between repairing cartilage and preventing the injuries that destroy it.

Why this work

My great-grandfather was a scientist. After undergoing an invasive procedure for suspected normal-pressure hydrocephalus, he was unsettled by its risks — and went on to develop a safer, non-invasive way to measure intracranial pressure. He taught me early that progress comes from questioning established practice and taking responsibility for improving it.

Early in medical school I sustained a cartilage injury in my hip, with a real possibility of progressing to osteoarthritis. A physician mentioned that stem-cell therapies might one day offer options for cases like mine. That is where this began.

Since then my work has followed two questions: how do we repair damaged tissue, and how do we keep it from being damaged in the first place?

Repair

Most cell-based approaches deliver reparative cells but leave untouched the pathobiology that keeps destroying the tissue. In osteoarthritis, the inflammatory synovial environment drives degeneration. My project targets both fronts at once — supporting chondrogenic differentiation and cartilage repair while strengthening anti-inflammatory signalling. It grew into a dedicated research line at my institution.

Prevent

I am building a startup around an algorithm that estimates joint-specific vulnerability and translates that risk into evidence-guided exercise programming — lowering the probability of injury and, with it, the long-term burden of joint disease.

33% of Brazilians over the age of twenty-five live with osteoarthritis, while bureaucratic hurdles delay treatments recognised elsewhere and waiting lists for joint replacement grow. This is the problem I intend to spend my career on.

At a glance

The path so far

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Ventures & outreach

Research

Presentations

Experience

Distinctions

Contact

Open to research collaborations in cartilage regeneration, orthobiologics and evidence synthesis.

maria.senger@aluno.fcmsantacasasp.edu.br